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Seminar Series: The effects of social stress on circadian rhythms and sleep-wake cycle

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Title: The effects of social stress on circadian rhythms and sleep-wake cycle
Speaker: Dr Dipesh Chaudhury PhD, Assistant Professor, New York University Abu Dhabi (NYUAD), United Arab Emirates
Time: June 03, 2022, 15:00 (IST), Friday
There is a close association between mood, the circadian system and sleep regulation. Sleep is necessary for the normal functioning of the brain during the waking state and disrupted sleep is a core feature of many psychiatric diseases including major depressive disorder (MDD). Moreover, chronic stress has detrimental effects on sleep. We assessed the link between stress and sleep in mice using the chronic social defeat stress (CSDS) paradigm. Stress-susceptible mice displayed increased fragmentation of Non-Rapid Eye Movement (NREM) sleep both pre-and post-stress. Moreover, we found that stress susceptible mice exhibited: (i) blunted diurnal rhythms in activity in neural circuits that may play a role in regulating daily rhythms in mood and (ii) decreased rate of photoentrainment. Our findings emphasized the interaction between stressed induced mood disorders, circadian rhythms and sleep.

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